Advance Peptide Therapeutics And GLP-1 Receptor Agonists (GLP-1 RAs) Faster With Proven Workflows From Discovery To QC
Analyzing GLP-1 receptor agonist (RA) drugs has become increasingly complex. Peptide structures, closely-related impurities, and rising demands for sensitivity, speed, and compliance are putting pressure on laboratories.
Agilent helps simplify these challenges with fully integrated, end-to-end workflows, with optimized solutions including automated liquid handling, biocompatible and bio-inert LC systems, ultra inert consumables, high sensitivity LC/MS, GC systems, dissolution testing, and spectroscopy. With proven, connected workflows from a single vendor, Agilent enables faster method development, confident data interpretation, and efficient progression from discovery through QC and manufacturing.
Agilent HILIC delivers enhanced resolution and high‑sensitivity detection
Agilent Altura Poroshell HILIC-Z columns paired with the Agilent 1290 Infinity III Bio LC system improve retention and separation of polar GLP‑1 peptides, enabling better resolution of closely-related impurities and variants.
“The deactivated HILIC-Z column substantially reduced the undesired analyte-surface interactions in the analysis of GLP-1 receptor agonist drug products. We observed at least a 30% increase in sensitivity and reduction in peak tailing for the analysis of acidic peptides and excipients. Peptide impurities eluting in the peak tail were hardly detectable when using conventional stainless-steel hardware.” Piotr Alvarez, Senior Scientist at RIC group, Belgium
- Impurity Profiling of GLP-1 Receptor Agonists by HILIC-MS
- HILIC Analysis of GLP-1 Receptor Agonists and Excipients
- Pushing the Boundaries of Chromatographic Separation with Inert HPLC Column Hardware
Accuracy you can trust: Confident peptide identity, purity, and impurity profiling
Ensure reliable identification, sequence confirmation, and impurity profiling. Find proven methods for analyzing identity, purity, related species, truncations, deamidation or oxidation, and aggregation.
- LC/MS Characterization of GLP-1 Receptor Agonist Oligomers and Other Elusive Impurities
- LC/MS-Based Characterization of Liraglutide and Impurities
- An In-Depth Analysis of Semaglutide, a GLP-1 RA
- Comprehensive Characterization of Multiple GLP-1 Analogs
- Access resources library
Profiling of forced degradation and process-related impurities, overcoming challenges
Achieve reproducible separations and quantification of impurities using optimized LC methods with orthogonal UV/MS detection, reference standards, and validated data processing.
- Stability and Impurity Monitoring of GLP-1 Therapeutic Peptide Retatrutide Using a 2D-LC/TOF MS Platform
- Confirmation of Peptide-Related Impurity Intact Mass
- Impurity Profiling of Tirzepatide Under Stress Conditions
- Analysis of a Synthetic Peptide and Its Impurities
- Efficient Method Optimization of Semaglutide Analysis
- Amino Acid Composition Test of Semaglutide and Liraglutide
- Access resources library
Boost efficiency and enhance productivity
Accelerate analysis and keep your workflows running smoothly with Agilent comprehensive expert services and solutions.
- Get off to a good start: Installation and relocation services
- Maximize uptime: Instrument maintenance, service plans, and repair
- Control regulatory risk: Compliance Consulting
- Accelerate productivity: Digital Lab Solutions
- Turn bottlenecks into breakthroughs: Automated sample preparation and liquid handling
Your expert partner
Reach your goals with a team of experts by your side.
- Strengthen analytical capabilities: Agilent University
- Get answers at your fingertips: Agilent Community
- Reduce your lab’s environmental impact: Sustainable lab solutions