Amorphous Stability: Mesoporous Silica For Poor Glass Formers

Polymeric solid dispersions have long been regarded as the preferred technology for developing amorphous pharmaceutical formulations. This method has been widely adopted due to its ability to enhance the solubility and bioavailability of poorly water-soluble drugs. However, despite its popularity, this approach is not without limitations, particularly when it comes to stabilizing compounds that are classified as poor glass formers. These compounds tend to have a high tendency to recrystallize, which poses significant challenges in maintaining their amorphous state over time. This webinar will delve into the theoretical underpinnings of amorphous stability, which focuses on the comparative performance of polymeric solid dispersions and mesoporous silica-based formulations.

Explore recent experimental data that highlights the promising potential of mesoporous silica in achieving superior stabilization of poor glass formers and how it offers a compelling alternative to traditional polymer-based strategies.