Asahi Static Compression Synthesis And Axial Compression Synthesis Columns

Pioneered by AKB two decades ago and continually improved since, the flow-through synthesis column serves as the reactor in mid- to large-scale synthesis processes. Fundamentally, such a column has two primary functions:

1. Retain a well-packed bed of solid support during a volumetrically turbulent and hours-long synthesis process.
2. Ensure an equal distribution of phosphoramidites and reagents to all beads in the packed bed.

Polymeric-based solid supports swell significantly in the presence of toluene and then shrink in the presence of ACN. The synthesis column must be able to handle these back-and-forth swings in volume over the course of the synthesis cycle.

Asahi Kasei Bioprocess offers two types of synthesis columns to address these challenges:

Asahi SCS Column™
Static compression synthesis column that has become ubiquitous with large-scale oligosynthesis – designed with a fixed but adjustable top plate, allowing the user to “set and forget” bed height.

Asahi ACS Column™
Builds on the SCS design by adding a slurry inlet port as well as an adjustable piston to enable axial compression of the support, simplifying column packing and unpacking.