Automated Batch Dispensing Of Pharmaceutical Ingredients

Automated dispensing systems are utilized throughout the pharmaceutical industry for the transfer and weighing of excipients, active pharmaceutical ingredients (API’s) and lubricants into a variety of containers and processes. The use of screw feeders in both loss-in-weight (LIW) and gain-in-weight (GIW) dispensing systems ensures the accurate metering of the product to the process or container below. Coperion K-Tron’s integrated material handling and feeding systems are available in a variety of dispensary configurations, dependent upon the material to be transferred, the containment levels required and the process requirements. Typical dispensary systems often include the integration of the Coperion K-Tron pharmaceutical line of pneumatic conveying equipment, as well as the high-accuracy line of pharmaceutical design screw feeders.

Products include:

• API’s (of varied potency levels)
• Excipients (e.g. microcrystalline cellulose MCC, hydroxypropylcellulose HPC, croscarmellose sodium, lactose hydroxypropylmethyl cellulose HPMC, silicone dioxide, titanium dioxide, povidone PVP, cross povidone, starch, etc.)
• Lubricants (e.g. magnesium stearate, calcium stearate, stearic acid, etc.)
• Diluents and fillers (e.g. salt, calcium phosphate)
• Binders (e.g. carnauba wax, corn starch, gelatin, sucrose)
• Coloring agents & preservatives (e.g. iron oxide, ferric oxide)
• Synthetic polymers (e.g. polyvinylpyrrolidone PVP , polyethylene glycol PEG)
• Glidants (e.g. fumed silica, talc, magnesium carbonate)
• Sweeteners and flavorings
• Vitamins and antioxidants
• Final formulation blends