Automation To Miniaturize In Vitro Assays To Achieve Superior And Cost-Efficient Results

In vitro screening assays are essential components of modern drug discovery, enabling the evaluation of drug candidates against a variety of biological targets. Successful execution of these assays demands sophisticated instrumentation, a steady supply of consumables (such as tips, plates, reservoirs, and troughs), and high-quality reagents — including enzymes, DNA, peptides, buffers, and proteins. However, when large libraries of candidates must be screened, the process can quickly become time-consuming and costly.

To address these challenges, the miniaturization of biochemical assays using advanced automation platforms has emerged as a powerful solution. By reducing reagent volumes and consumable usage, this approach not only cuts operational costs but also significantly increases throughput and efficiency. In this article, we present a study conducted by Aragen’s expert scientific team, showcasing the successful application of miniaturized biochemical assays to screen a diverse range of drug candidates against multiple target molecules.