GE Healthcare Life Sciences launches Capto™ Core 700 Chromatography Medium For Viruses And Other Large Biomolecules

High productivity alternative to group separation for intermediate purification and polishing, offering higher sample loads and flow rates than gel filtration

GE Healthcare's Capto Core 700 is a multimodal chromatography medium (resin) designed for intermediate purification and polishing of viruses and other large biomolecules. Capto Core 700 offers a range of performance advantages over a typical gel filtration step. Productivity is improved with up to 100-fold greater sample loadings and significantly higher flow rates. Optimization and scale-up are both straightforward.

The Capto Core 700 medium employs core bead technology, with a ligand-activated core and inactive outer layer. The inactive outer layer excludes large molecules (Mr 700 000 [700 kDa] and above) from entering the beads which can subsequently be collected in the column flowthrough. Smaller impurities bind to the internalized ligands, which are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core.

With Capto Core 700, flowthrough chromatography and a wide window of operation enable straightforward optimization. The prepacked HiTrap™ and HiScreen™ formats simplify process development and scale-up. Capto Core 700 is also available as a bulk medium in a range of pack sizes from lab scale to production-scale.

About GE Healthcare
BAC discovers, develops and manufactures separation and affinity purification products for use across the value chain of biopharmaceutical R&D and manufacturing. Based on BAC's proprietary single-chain antibody technology called CaptureSelect, the products are suitable for the discovery, preclinical and clinical manufacturing of therapeutic proteins, including antibodies and antibody fragments. They enable a reduced time to market, increased purity and yield and an overall lower cost of goods for biopharmaceutical drug development. BAC BV was established in 1995 as a Unilever subsidiary and is collaborating with the leading life sciences vendors. Currently the Company employs 37 people with an R&D laboratory facility in Leiden and a state-of-the-art ISO 9001 certified manufacturing plant in Naarden, the Netherlands. For further information please visit www.gelifesciences.com/captocore

Source: Cytiva