Cell Line Development Toolbox For The Development Of Intensified CHO Processes

By Dirk Mueller, Nico Erb, Michael Grauf, Lukas Klein, Gernot Stipek, Marisa Bertram, Fabian Vogt, and Gerben Zijlstra

Intensified process formats promise improved cost efficiency in biotherapeutics production through lower cost of goods and increased plant flexibility. CHO clones from traditional cell line development differ in responsiveness to process intensification, so efficient approaches for selecting suitable clones and developing associated USP processes are needed. This poster outlines a USP toolbox that can be applied to assess the suitability of clones for the intensification and the development of different types of intensified processes.