Characterization And Mapping Of Active Pharmaceutical Ingredients And Excipients In A Tablet By Raman & Infrared Spectroscopy On The Same Microscope
Application Note: Characterization And Mapping Of Active Pharmaceutical Ingredients And Excipients In A Tablet By Raman & Infrared Spectroscopy On The Same Microscope
Aim of the measurements:
The goal of this analysis was to determine the identity and dispersion of components in a competitive pharmaceutical tablet. These parameters were determined by a combination of Raman and FT-IR microspectrometry.
Conditions of measurements:
The presented data here was measured on the Jobin Yvon
LabRAM IR, the award winning system which combines the
LabRAM Raman microscope with the Smiths IlluminatIR FT-IR
microscope on one optimized single platform. The combination
of these two complimentary techniques on a single microscope
allows quick identification of the ingredients used in the tablet.
The Raman spectra were acquired by using a 633nm excitation
laser. The IR spectra were acquired at 4cm-1 spectral
resolution using the Diamond ATR objective. Each IR spectrum
represents a collection time of one minute twenty seconds. The
spectra have been adjusted for the frequency dependence on path
length due to the ATR technique.
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Application Note: Characterization And Mapping Of Active Pharmaceutical Ingredients And Excipients In A Tablet By Raman & Infrared Spectroscopy On The Same Microscope
SOURCE: Smiths Detection