Chromatography Column Protection With 3M Purification LifeASSURE™ PLA Series Membrane Filters

Protective, or guard, filters are often used in chromatography column purification steps to protect the column media from contaminants in the various fluids that come in contact with the column. These fluids include not only the product being purified, but also the buffer solution used to elute the column, as well as rinse water and regeneration and CIP chemicals. All these fluids, if not clean, can result in poor column efficiency, channeling of the media, blockage of the inlet fritt, or bacterial contamination of the column.

This Application Brief discusses an alternative chromatography column protection filter, LifeASSURE™ PLA series filter.