Brochure: CleanScan™

Cleaning validation is a very important issue in the batch production of pharmaceuticals. Production run campaigns are followed by periods of 'Change-Over' and this can have considerable impact on the production capacity. A reactor has to be thoroughly cleaned by a validated process before the next production cycle can start and large volumes of solvent such as methanol and acetone are used. Samples from the wash cycle are measured off-line that is time consuming and costly. Final analysis is typically by a swab samples and HPLC. The solution is to install an on-line analyser that has a fast response time and sensitivity to monitor the status of the cleaning process in real time.