Cleavage And Deprotection Systems To Enhance Production Safety And Efficiency

Our mid- to large-scale C&D Systems allow you to automate the cleavage and deprotection steps while increasing productivity by freeing up your oligosynthesizer to focus on its core job of synthesis.

Solid phase synthesis using flow-through columns has become the proven method for reliably producing antisense, RNAi and other therapeutic oligonucleotides by manufacturers. After synthesis, the oligo must be cleaved from the solid support and conditioned for further downstream processing.

To streamline and automate this overlooked unit operation, Asahi Kasei Bioprocess offers a family of Cleavage and Deprotection (C&D) Systems for your clinical- and commercialscale oligonucleotide manufacturing needs.

Available in flow rates starting at 180 L/h up to 2000 L/h, C&D Systems are designed to accommodate both DNA and RNA processes.