By James Ellis, Hanningfield Process Systems
In many pharmaceutical processes, what works in the lab doesn’t always scale-up seamlessly into production; this is true in conical milling. Larger batches, different process conditions, and varying material characteristics can all create unforeseen problems that ultimately impact performance. Despite this, lab and pilot milling can still be a great indicator of scale-up output, and certain steps can be taken to maximize the likelihood of successful production. This white paper will aim to help you scale-up with minimum disruption or deviation. While there is no silver bullet, identifying potential pitfalls while understanding best practice can at least provide a logical road map for achieving milling success.