Many factors can necessitate a mix of continuous flow and batch manufacturing processes, which is often the first step towards multi-step flow processes. This application brief outlines two examples.
In the first example, the first production run of a low-temperature deprotonation and alkylation had been performed in batch mode for expediency. Compound 3 was prepared in large cryogenic kettles (3000 L).
The second example adds continuous flow to an established commercial process for the carbapenem market to reduce costs.