Corona® CAD™ HPLC Detector
HPLC Detector — Based on a unique, innovative detection method, the Corona® CAD™ HPLC detector offers all-in-one performance benefits that refractive index (RI), low wavelength UV, evaporative light scattering (ELS), and chemiluminescence nitrogen (CLN) detectors simply can't match.
All the best performance – and then some – in one revolutionary detector.
What's the best way to detect and measure compounds with your HPLC? There is no simple answer. UV detection is the most widely used, but can fail to detect or correctly measure many compounds of interest. Other, so-called universal detectors have fallen short of the promise of combining application versatility with real performance.
But today, the landscape in universal HPLC detection has changed. Now there is an alternative unlike any other - the Corona® Charged Aerosol Detector. Based on a unique, innovative detection method, the Corona detector offers all-in-one performance benefits that refractive index (RI), low wavelength UV, evaporative light scattering (ELS) and chemiluminescence nitrogen (CLN) detectors simply can't match:
- Excellent sensitivity
- Superior reproducibility
- More consistent response
- Wide dynamic range
- Broad applicability
- Intuitive operation
What makes the Corona detector unique – charged aerosol detection technology.
CAD™ (Charged Aerosol Detection) is a unique technology, in which the HPLC column eluent is first nebulized with nitrogen, and the resulting mobile phase droplets are dried to remove mobile phase, which produces analyte particles.
A secondary stream of nitrogen becomes positively charged as it passes a high-voltage, platinum corona charger. This charge is mixed with the analyte particles and charge is transferred to the analyte particles through an absorptive, collision/defusion based mechanism that allows for detection of any non-volatile molecule.
The charge from the analyte particles is then transferred to a collector, where it is measured by a highly sensitive electrometer, generating a very uniform signal in direct proportion to the quantity of analyte present.
Ideal for a wide range of applications.
Corona Charged Aerosol Detection is applicable for virtually any non- or semi-volatile compound, and has been widely applied in areas such as:
- Analytical Method Development and Transfer
- Compound and Product Degradation Studies
- Impurity Testing
- Product Formulation and Excipient Characterization
- Cleaning Validations
- Measurements of Biomolecules (Proteins, Peptides, Lipids, Carbohydrates)
- Measurement of Polymers, Detergents and Surfactants