Application Note

Development And Characterization Of The Species-Specific Liver-Chip

Source: Emulate
GettyImages-1441662840-lab-team-communication-collaboration

The early stages of drug discovery and development involve studies mandated by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency to assess the safety of a potential therapeutic compound before it advances to the clinic.

Preclinical testing requirements primarily rely on two approaches: in vitro models and in vivo studies utilizing rodent and non-rodent animal models. Current in vitro models inadequately replicate three-dimensional cellular architecture and lack physiologically relevant environments, and animal models often poorly predict human responses due to species differences. Consequently, this hampers effective nonclinical to clinical translation.

In the pharmaceutical industry, there is a growing need for preclinical models that closely mimic human physiology to facilitate a deeper understanding of drug mechanisms. Organ-Chips offer a solution, as they replicate in vivo-like functionality within a more physiologically relevant microenvironment than conventional cell-based models. Explore how the Chip-S1 system can generate a comprehensive recapitulation of the liver sinusoid.

access the Application Note!

Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Pharmaceutical Online? Subscribe today.

Subscribe to Pharmaceutical Online X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.

or

Subscribe to Pharmaceutical Online