White Paper

Drastically Reduced Isolator Decontamination Cycles

Source: Optima Packaging Group GmbH

By Felix Henning, Optima Packaging Group GmbH 

With the use of catalytic aeration, M + P is able to reduce the duration of the aeration phase in isolators by about 50 %. The aeration phase is the most time consuming cycle during H2O2 decontamination. Decontamination with VHP (Vaporous Hydrogen Peroxide) regularly takes place prior to production. Existing M + P isolators can also benefit from this development with a simple upgrade. A patent has been applied for.

Isolators are considered to be the safest method for guaranteeing a sterile filling environment in pharmaceutical production. In isolators, a vaporizer combined with a distribution system takes over the automated decontamination. M + P long ago decided on a system with distribution nozzles for dispersion of the H2O2. This decision also proves to be a decisive advantage for the newly developed catalytic aeration. Other isolator manufacturers use fans to distribute H2O2 in the process area (filling and capping). When recirculation fans are used, however, catalytic aeration cannot be performed without simultaneously negating the decontamination cycle.