Drop-In, Fit-In, & Built-In Sorbent Solutions For Respiratory Drug Delivery Devices

Formulation and device technologies for respiratory drug delivery (RDD) are changing rapidly, but physical stability, chemical stability, and accurate dosing remain paramount concerns for pharmaceutical manufacturers and device design engineers.

Manufacturers of HFA aerosol inhalers have the unique challenge of working with a very hygroscopic propellant that not only results in moisture ingress into the dosing chamber, but also into the pressurized primary package. This often results in hydration/crystallization of the drug substance and/or corrosion of sensitive inhaler device components, leading to chemical and physical instability and dosing problems.

Dry Powder Inhaler (DPI) manufacturers often face moisture-induced physical stability problems that can't be resolved via the use of a simple sorbent consisting of silica gel or molecular sieve. Specifically, DPI formulations often require an intelligent moisture management system that balances the common DPI issues of particle agglomeration (too wet) and triboelectrification (too dry) to provide for physical stability, chemical stability, and proper dosing.

Multisorb offers intelligent sorbent solutions designed to manage moisture, oxygen, odors, and/or volatized hydrocarbons to protect RDD drug formulations from degradation and extend shelf life through the supply chain and consumer use. They can be incorporated into drug product packaging and device designs via Multisorb's Drop-In, Fit-In, and/or Built-In solutions.