Evolution Of A Novel Polymer To Overcome Limitations In Sustained Drug Delivery

Drug delivery systems can enable an improvement in a drug's therapeutic efficacy while minimizing unwanted effects. These systems are often composed of a polymeric vehicle containing an active pharmaceutical ingredient (API) designed to release at the site of disease or trauma.

Recognizing opportunities for design improvements, an evolution of degradable polymers occurred from aliphatic polyesters to nitrogen bearing biomaterials such as polyurethanes, polyester amides, and polyureas. This evolution was needed to provide biomaterials which demonstrate improved control over degradation, material, and drug release properties. Naturally, this has also led to hybrid material designs, such as combining the biodegradability of polyesters with the excellent biocompatibility and more hydrophilic nature of polyamides.

This article describes a brief history of the development of Polyester Amide (PEA) polymers.