Face The Unknown: Efficiently Select And Optimize Antibody Candidates Using Surface Plasmon Resonance

The journey to gaining a deeper understanding of disease pathways or discovering new therapeutics is both complex and demanding. Selecting the right antibody or antibody variant for clinical development involves a thorough evaluation of its functionality and target-binding characteristics. Depending on the therapeutic target, different binding affinities may be required. Some targets demand high-affinity interactions to ensure effective blockade or modulation, while others may perform better with lower-affinity binding to maintain physiological balance. For instance, bispecific antibodies must strike a delicate balance in their affinity for two distinct targets to minimize the risk of off-target effects. Beyond binding properties, these candidates must also demonstrate ease of expression, correct assembly with minimal aggregation, and high structural stability. To support researchers in this multifaceted endeavor, we offer a suite of tools and services designed to empower your work. Our expertise, combined with cutting-edge technology solutions, can help accelerate your research and enhance reliability at every stage of the development process—now and into the future.

This ebook explores how surface plasmon resonance (SPR) and Biacore™ SPR systems play a pivotal role throughout the antibody research pipeline. From the initial selection of candidate molecules to the identification of clinical leads, these technologies provide valuable insights that drive informed decision-making and successful therapeutic development.