Flamma Group - Isso Site

Located in Bergamo, Italy, the Isso site supports small‑molecule programs from early development through commercial manufacturing with a combination of scale, containment, and specialized processing capabilities. The facility is designed to handle complex chemistries and demanding operating conditions, including cryogenic reactions down to –90°C, high‑pressure processes, and potent compounds requiring stringent OEL controls. Integrated process development, analytical development, and process safety expertise help de‑risk scale‑up while maintaining momentum across clinical phases.

Production infrastructure spans glass‑lined and stainless‑steel reactors from kilo to multi‑ton scale, supported by advanced solid‑state characterization, in‑process monitoring, and flexible downstream equipment. Dedicated technologies enable safe handling of challenging reagents such as thionyl chloride and anhydrous ammonia, while robust containment and material transfer systems protect both product quality and personnel. With AIFA inspection, ongoing investments in labs and equipment, and room for future expansion, the site offers a reliable pathway from development to commercial supply.

Read the brochure to see how these capabilities come together to support complex API programs with precision and confidence.