Flow Chemistry: A Scale-Up Solution For Modern API Development And Manufacturing

By Peter Pöchlauer, Thermo Fisher Scientific

Once deemed an “experts-only” approach to chemical synthesis, flow chemistry is a cost-efficient technique growing in popularity that can increase safety and flexibility and improve product quality. However, not all chemical profiles perform better under flow conditions. Thus, you must know how to evaluate whether your API will perform better with batch versus flow chemistry, as this dictates not only the process you will use for scale-up but also the facility and expertise needed to do it successfully.