Case Study: GlaxoSmithKline South Africa - Quality And Efficiency At The Heart Of New Manufacturing Facility

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•Case Study: GlaxoSmithKline South Africa - Quality And Efficiency At The Heart Of New Manufacturing Facility

GSK Sth Africa in Cape Town manufactures Albendazole Tablets, which have been remarkably successful in the treatment of LF (Lymphatic Filariasis or Elephantiasis), one of the most disfiguring and disabling tropical diseases.

GSK recently commenced production in a new extension to the existing facilities.

The Company has a strong commitment to driving improvement, increasing the robustness of the manufacturing process, reducing waste and maintaining the highest quality standards. In designing the new plant they paid particular attention to specific process steps where efficiencies and quality could be improved.

The solid dosage manufacturing process is batch based and uses Intermediate Bulk Containers (IBCs) to move batches between process steps.

The process is quite simple and involves the following steps:

• Raw-material dispensing to an IBC;
• Blending in the IBC;
• Roller compaction of the blended batch;
• Further raw-material dispensing to the IBC;
• Further blending in the IBC;
• Compression of the compacted batch into tablets

From past experience, GSK identified the roller compaction step as a critical "risk" area. In order to ensure content uniformity and avoid flake degradation in the compacted batch it is vital that the roller compactor in-feed receives material in a consistent, controlled manner.

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•Case Study: GlaxoSmithKline South Africa - Quality And Efficiency At The Heart Of New Manufacturing Facility

SOURCE: Matcon Americas (IDEX MPT Incorporated)