Headspace Gas Ingress To Replace Dye Ingress CCI Testing

This video presents an innovative and modern approach to container closure integrity testing, which offers a compelling alternative to the traditional dye ingress method. It showcases the integration of a tracer gas—specifically carbon dioxide (CO₂)—with non-destructive headspace analysis to detect potential leaks in pharmaceutical vials. Viewers will walk through a detailed, step-by-step process in which vials are carefully placed inside a sealed test vessel filled with CO₂ tracer gas. If a vial has a leak, the gas penetrates the container during the exposure phase. Following this, the vials undergo analysis using a high-precision LIGHTHOUSE headspace analyzer, which measures the internal gas composition of each vial.

Discover how this sensitive detection method accurately identifies which vials have compromised seals to provide a clear and analytical assessment of container integrity. By eliminating the need for destructive testing and offering enhanced sensitivity, this technique represents a significant advancement in ensuring product safety and quality in pharmaceutical packaging.