A Guide To Homogenization in the Pharma, Biotech and Cosmetic Industries

High-pressure homogenization is essential to the quality and stabilization of beauty creams, lotions, nail varnishes, shampoos, toothpastes, and emulsions containing different oils since it is a very effective way to create the exact required product texture (via particle size reduction) while at the same time creates very stable product compared to the traditional devices such as agitators, stirrers, rotor-stator devices or colloid mills. This is achieved by reducing the particle size and uniformity under conditions of extreme pressure, shear and stress. The result is a homogeneous effective product with superior stability and shelf life.

High-pressure homogenization in the pharmaceutical industry has proven its ability to make more stable product, with better active ingredient dispersion, than has been achieved with conventional stirrers, rotorstator devices or colloid mills. It achieves this by reducing the particle size and uniformity under conditions of extreme pressure and stress. The result is a more clinically effective product with greater stability and shelf life.

A typical Niro Soavi homogenizer for pharmaceutical applications features the following:

• Very high pressure (VHP) design
• High wear resistant parts and homogenizing valves
• cGMP Pharma design
• All wetted parts are electro-polished, final surface roughness Ra<0,5µm
• FDA approved gaskets
• Certification Manual for Pharma validation cGMP
• Special aseptic execution with closed loop aseptic circuit
• Cleaning-in-Place (CIP) and Sterilization-in-Place (SIP) –able
• Sanitary pocketless design is free draining
• Designed to be fully compliant with 21 CFR (Code of Federal Regulations) PART 11