White Paper

Hot Melt Extrusion: Improving Solubility Of Poorly Soluble Compounds

By Srinivas Ajjarapu, PhD, Formulation Scientist, and Venketa Raman Kallakunta, PhD, R&D Manufacturing Scientist, Thermo Fisher Scientific

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Solving solubility challenges before they become long-term issues is critical for the success of your small molecule project. One potential development and manufacturing option to address solubility challenges is implementing a hot melt extrusion (HME) strategy to manufacture amorphous solid dispersions (ASDs).

Leveraging HME solutions can result in solvent-free processing, reduced cost of goods (COGs), and continuous manufacturing. As you build out your HME strategy, there are a variety of considerations around pharmaceutical applications, formulation, and processing to ensure your strategy is flexible, robust, and comprehensive.

Review formulation and processing considerations for the HME process, pharmaceutical applications, and Thermo Fisher Scientific capabilities.

VIEW THE WHITE PAPER!
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