How Can You Get Two Or Three APIs To Play Nice In One Capsule?

By Lonnie Barish

Oral solid dose (OSD) delivery remains the most popular route for administering drugs. Market forces are prompting pharmaceutical companies to pursue a broad array of OSD development strategies to make their active pharmaceutical ingredients (APIs) and formulations therapeutically effective and patient friendly.

One choice that is growing in popularity to control dose frequency and side-effects are compressed, tablet form multiple-unit pellet systems (MUPS). A versatile technology integrating proven pelletization and tablet delivery modalities. MUPS delivery offers new modified-release profiles and the dosing precision pharma needs for its advanced formulations and potent, combined APIs. It’s a great way to get multiple APIs to “play nice” together. This technology is not new and has been used in the food and chemicals business for many years with many commercially available products, e.g. slow release fertilizers and flavorings.