How To Improve API Solubility By Salt And Cocrystal Formation

The development of new active pharmaceutical ingredients (APIs) is a complex, time-consuming, and costly process. Therefore, it is crucial to mitigate any potential risks that could hinder the product's success. A significant challenge in this field is that many APIs are not commercialized due to their poor water solubility, particularly those classified as BCS class II and IV. This poor solubility leads to low bioavailability, making the drugs less effective.

To address this issue, various API processing techniques have been developed to enhance drug solubility, stability, and processability. Among these techniques, salt formation and cocrystal formation are particularly noteworthy. Understanding when to use these methods, how to select the appropriate coformers for your API, and how to navigate potential obstacles is essential. By mastering these techniques, you can focus on bringing your product to market rather than being bogged down by solubilization challenges.

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