Improving API Particle Size Distribution Targets — Is There A Better Way?

By Wilf Sangüesa, P. Eng, Quadro Engineering

Milling is an integral step in API production; however, not all size reduction methodologies offer the same level of narrow particle size distribution spans, nor an easy, repeatable and accurate ability to control particle size range outputs. As companies strive for better manufacturing efficiencies – selection of the most suitable equipment for the application, needs to be paired with options offering the greatest return-on-investment. This Paper explores the background of API milling from a technology perspective – reviewing traditional comminuting methodologies, and exploring new, innovative breakthroughs in conical milling size reduction.