Improving API Solubility Using Hot Melt Extrusion Formulation With Polyvinyl Alcohol

In the pharmaceutical industry, enhancing the solubility of active pharmaceutical ingredients (APIs) is crucial for effective drug delivery. One innovative approach to achieve this is through hot melt extrusion (HME) using polyvinyl alcohol (PVA). This application note from MilliporeSigma delves into the advantages of HME with PVA, highlighting its ability to improve the solubility and bioavailability of poorly soluble APIs. Investigate the process of hot melt extrusion, where APIs are dispersed in a polymer matrix at elevated temperatures, which results in a solid dispersion to enhance solubility.

Polyvinyl alcohol, a versatile and biocompatible polymer, is particularly effective in this process due to its excellent film-forming properties and stability. The use of PVA in HME not only improves the dissolution rate of APIs but also ensures uniform distribution and consistent drug release profiles. Furthermore, various case studies and experimental results demonstrate the efficacy of HME with PVA in real-world applications. Explore the full potential of hot melt extrusion with polyvinyl alcohol and understand how it can revolutionize your pharmaceutical formulations.