Improving API Solubility Using Spray Drying With Polyvinyl Alcohol

The limited solubility of active pharmaceutical ingredients (APIs) remains one of the most persistent and critical challenges in modern drug development. Poorly soluble APIs often exhibit reduced bioavailability, which can compromise therapeutic efficacy and hinder successful clinical outcomes. Addressing this issue requires a multifaceted approach aimed at enhancing the solubility and dissolution rate of the drug compound. Advanced processing technologies like hot-melt extrusion and spray drying have proven effective in transforming poorly soluble APIs into more bioavailable forms. These methods, often used to create amorphous solid dispersions or improve wettability, are integral to modern formulation science.

Learn how leveraging these innovative techniques can help pharmaceutical developers significantly improve the performance of challenging drug candidates.