Improving Productivity And Purity In ADC Polishing With Sartobind® Q Membranes In Rapid Cycling Mode

Antibody–drug conjugates (ADCs) are transforming oncology, but their purification remains complex and costly. This success story highlights how a medium-sized CDMO replaced traditional packed-bed chromatography with Sartobind® Q membrane adsorbers in rapid cycling mode to intensify their ADC polishing process. The shift resulted in a dramatic 40-fold increase in productivity, cutting process time nearly in half and reducing buffer consumption by over 800 liters. The membrane’s single-use design also minimized validation requirements and operator risk. By eliminating the need for resin packing equipment and reducing facility footprint, the company achieved a 15% cost reduction while improving aggregate clearance and overall product quality.

Explore the full case study to see how rapid cycling chromatography can reshape downstream processing.