Influence Of L-Leucine Content On The Internal And External Morphology Of Spray Dried Particles

Developing effective spray-dried particles for pulmonary drug delivery requires balancing surface composition with internal structure. Recent insights reveal how adjusting L-Leucine concentrations significantly alters both particle morphology and API protection. At lower concentrations, the structural impact remains minimal. However, escalating L-Leucine levels drives progressive internal porosity and cavity formation, culminating in particle fragmentation at high thresholds.

Simultaneously, L-Leucine preferentially migrates to the surface to form a protective, moisture-resistant shell, keeping the active pharmaceutical ingredient securely internalized within the core. Introducing surfactants like Polysorbate 20 further refines this process, yielding more uniform internal porosity and enhanced surface enrichment. Understanding these structural transformations is vital for optimizing particle density and aerodynamic behavior.

Download the full poster to explore the cross-sectional imaging and surface analysis mapping that support the rational design of inhaled therapies.