Product/Service

Injectable Drug Development

Source: Interpharm Press, Inc.
Intravenous, subcutaneous, and intramuscular injection of parenteral formulations are important and critical routes
Intravenous, subcutaneous, and intramuscular injection of parenteral formulations are important and critical routes of administration when oral ingestion of drugs is contraindicated. The increasing importance of biotechnology and the development of increasing numbers of therapeutic peptides and/or gene products into the twenty first century necessitates a better understanding of the interactions between parenteral formulations and site injections. This book provides in-depth details designed to inform you of all considerations.

26 experts from the United States and Europe offer both an overview of the basics and an in-depth understanding of this complex area by providing an interdisciplinary approach including pharmaceutics, physiology, anatomy, toxicology, and product formulation.

Chapters Include:
Challenges in the Development of Injectable Products, Mike Akers / Pain, Irritation, and Tissue Damage with Injectables, Wolfgang Klement / Mechanisms of Muscle Damage with Injectable Products, Anne McArdle & Malcolm Jackson / In Vitro Methods for Evaluating Intravascular Hemolysis, Joseph Krzyaniak & Samuel Yalkowsky / Lesion and Edema Models, Steve Sutton / Rat Paw-Lick and Mouse Scratch Models, Pramod Gupta / Radiopharmaceuticals for the Noninvasive Evaluation of Inflammation Following Intramuscular Injections, Agatha Feltus, Michael Jay, & Robert Beihn / A Primer on In Vitro and In Vivo Cytosolic Enzyme Release Methods, Gayle Brazeau / Histological and Morphological Methods, Bruce Carlson & Robert Palmer / A Conscious Rat Model to Assess Pain Upon Intravenous Injection, John Marcek / Co-Solvents in Injectable Formulations, Susan Way & Gayle Brazeau / Pro-Drugs, Laszlo Prokai & Katalin Prokai-Tatrai / Complexation -- Use of Cyclodextrins to Improve Pharmaceutical Properties of Intramuscular Formulations, Marcus Brewster & Thorsteinn Loftsson / Liposomal Formulations to Reduce Irritation of Intramuscularly and Subcutaneously Administered Drugs, F. Kadir, C. Oussoren, & D. Crommelin / Polymeric Microspheres, Elias Fattal / Emulsions, Pramod Gupta & John Cannon / Optimization of Injectable Formulations, Larry Gatlin & Carol Gatlin

Interpharm Press, Inc., 15 Inverness Way E., Englewood, CO 80112-5776. Tel: 303-662-9101; Fax: 303-754-3953.