KinetiSol™ Technology
This solvent-free process uses rapid frictional and thermal energy to create stable amorphous dispersions in seconds, enabling high drug loads, improved bioavailability, and easier scale-up.
The Expanding Drug Design Space
New molecules emerging from discovery continue to deviate further from conventional drug-like properties. We are expanding the boundaries of the chemical drug space as we search for new and better compounds. Consequently, the percentage of poorly soluble drugs in the pipeline continue to grow. Since a drug’s solubility is critical for absorption within the digestive tract, this trend places tremendous pressure on formulation scientists. Since 2007, AustinPx has been developing the KinetiSol Technology to address the need of improving bioavailability of poorly soluble drugs.
A fusion-based, solvent-free process that utilizes frictional and shear energies, KinetiSol rapidly transitions crystalline drug and polymer into an amorphous solid dispersion (ASD). KinetiSol has been applied to some of the most poorly soluble molecules, including deferasirox, abiraterone, tetrabenazine, and vemurafenib, and has proven to be a bioavailability enhancement solution at all levels of development.
KinetiSol’s unique and highly optimized equipment design offers many advantages over other amorphous dispersion technologies including:
- Broader Solution Platform: Applicable to a wider range of molecules including molecules with high melting points and poor solvent solubility, a broader formulation design space, and improved drug loading
- Lower development costs: Streamlined scale-up and significantly faster processing times
- Greener Technology: No solvents required, smaller physical and operational footprint
- Extended product life cycle: Possible IP creation through patented processing technology and composition of matter patents.
Formulation Development and Manufacturing with KinetiSol Technology
AustinPx offers comprehensive development, analytical testing and GMP manufacturing support for KinetiSol Technology enhanced APIs at all stages of development, including the handling of highly potent molecules. KinetiSol Technology has been developed at research and production scales to ensure speed to clinic and easy scale up to commercial production.