Less Mess, Less Stress, Best Expressed: A Superior Alternative To Spray Drying

By Chris Brough, AustinPx

Spray drying is a well-established process, and it is the de-facto standard in pharmaceutical amorphous solid dispersion (ASD) formulation and manufacturing today. Hot-melt extrusion (HME) was developed as a more environmentally friendly production alternative, but it cannot be used for thermolabile APIs and polymers, greatly limiting its applicability.
KinetiSol ― a fusion-based process for the manufacture of amorphous solid dispersions ― has existed in the plastics industry for decades, yet only in the past ~15 years has it become available and competitive within the pharmaceutical industry. In that relatively short time, it has proven to outperform competing technologies by numerous metrics, including bioavailability, cost-savings, manufacturing speed, environmental impact, and more.

KinetiSol uses no solvents and no nitrogen: no chemicals to acquire, store, or dispose of. It also helps to reduce operating costs by eliminating the multiple manufacturing steps associated with spray drying and is a fee-for-service technology. No licensing is required to access it and no royalties are required. It has been installed at multiple CDMOs and can be added as part of companies’ in-house production lines.