Lipid-Based Formulation Technology

Lipid-based formulation (LBF) approaches — encompassing the use of lipid excipients, solvents, co-solvents in liquid, semi-solid or solid formats — are a key tool for improving solubility. LBF is primarily used for bioavailability enhancement, along with addressing food effects and associated variability. Additionally, liquid or semi-solid LBF approaches are routinely utilized for low dose/highly potent applications, due to the ability to achieve uniform API distribution at low dosing, and to minimize exposure hazard.

Lonza has premier technology depth in LBF, and specialized capabilities in LBF-based dosage forms to address poor API aqueous solubility and other formulation challenges. You can leverage this extensive expertise in LBF — utilizing liquid-filled hard capsules, soft gels and lipid multiparticulate approaches — to support projects from early design stages through commercial-scale manufacturing.