Lipid Formulations In Softgels: Enhancing Bioavailability And Therapeutic Efficacy

Achieving optimal bioavailability of active pharmaceutical ingredients (APIs) is critical to therapeutic success. For poorly soluble compounds, lipid-based formulations — particularly those delivered in softgel capsules — can offer an effective approach to improving drug absorption.

By leveraging the body’s natural digestive processes in the gastrointestinal (GI) tract, lipid formulations can enhance API solubilization and absorption and, in some cases, promote lymphatic transport. This can be especially valuable for poorly soluble compounds that are subject to extensive first-pass metabolism, including certain hormones and other therapeutic agents.

In this on-demand webinar, two Thermo Fisher Scientific experts in softgel technology share insights into how lipid-based formulations can improve drug absorption and bioavailability. The session explores a range of lipid systems — including solutions, suspensions, emulsions, and self-emulsifying and self-microemulsifying formulations — and examines their applications across therapeutic areas such as HIV, oncology, immunosuppression, and emerging treatments such as medicinal cannabis, including CBD.