Mannogem EZ Granular Mannitol

SPI Pharma Group is pleased to introduce our new spray dried mannitol. This product is designed to assist the formulator in blending and compressing with actives that are difficult to tablet.

Mannitol is the preferred excipient for chewable tablets due to its favorable mouthfeel. Mannitol is nonhygroscopic. It does not add moisture or contribute to moisture pickup and is also chemically inert. These properties make mannitol a useful excipient for tablets because it protects water-sensitive actives from degradation and does not react with the active. Mannitol does not undergo the Maillard reaction and therefore does not discolor in the presence of free amines.

Mannogem EZ Granular Mannitola spray dried product that has a very narrow particle size distribution, excellent mouthfeel, superior flow properties and a very good compression profile.

Typical Properties vs standard Mannogem Granular Mannitol

	Mannitol Assay	Particle Size	Comments
Mannogem Granular Mannitol	96-100%	170-1190 m	USP, EP, nonhygroscopic, directly compressible
Mannogem EZ	96-100%	150-200 m	USP, EP, nonhygroscopic, directly compressible

 

This grade should be used when a narrow particle size range is required in order to avoid segregation from the active. Mannogem EZ also allows the formulator to achieve appropriate hardness for chewable tablets at lower compression forces.

Figure 1 shows the compressibility of Mannogem EZ in comparison with our standard Mannogem Granular Mannitol.

Selecting the right SPI Pharma grade of mannitol allows the formulator to make a high-quality pharmaceutical product. The SPI Pharma technical staff can assist you in choosing the right product for your application.

LETS FOR LEFT SIDE

Directly Compressible

Superior particle size uniformity

EZ flowing

Good mouthfeel

SPI Pharma, 321 Cherry Lane, New Castle, DE 19720. Tel: 302-576-8500; Fax: 302-576-8892.