Article | November 17, 2021

Mechanistic Modeling For Downstream Processing: Digital Twins Are Here To Stay

Source: Cytiva

By Tobias Hahn, Principal Scientist, Cytiva


Across many industries, computer simulation has become an essential tool. Bioprocess development is only beginning to establish simulation-based workflows, despite the innovative nature of the biopharmaceutical industry.

Experts in the bioprocess industry agree that expensive and time-consuming laboratory experiments, iterative empirical optimization, and statistical methods alone cannot tackle future challenges. Therefore, many global biopharma companies are working on establishing digital twins of their upstream or downstream processes.

This article explores the types of digital twins as well as mechanistic modeling and chromatography models for the prediction and optimization of existing processes. Discover the important role that fully developed digital twins are likely to play.

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