Milling API Slurries

High shear rotor-stator mixers such as the Quadro Ytron® Z Emulsifier and Quadro® HV (High Velocity) Wet Mills are used extensively in the Food, Personal Care, and Chemical Process industries for high shear processing of emulsions, suspensions, and many semi-solid liquid products. In the Pharmaceutical industry, the Quadro Ytron® Z Emulsifier and Quadro® HV are also employed as slurry and "wet mills" for particle size reduction of API slurries. API materials typically undergo a size reduction step prior to incorporation into a final pharmaceutical dosage tablet or vaccine. Wet mills are often used for conditioning slurries when the API is highly potent and dry handling is undesirable. They are also used for compounds that are susceptible to degradation (i.e. crystalline materials) during dry milling. Wet Milling, using a Quadro Ytron® Z Emulsifier and Quadro® HV can also be employed in a pharmaceutical milling suite as a pre-milling device, to reduce process time or the number of passes in a media mill or other high energy operation. The equipment best-suited for the application depends on the amount of energy required to mill or emuslify the compound to the target particle/droplet size.