Moisture Activated Dry Granulation (MADG): An Innovative Way To Make Pharmaceutical Processing Easier

Mesoporus silica excipients offer pharmaceutical formulators an innovative way to modify wet granulation. It’s moisture activated dry granulation (MADG) technique provides a way to address common problems such as endpoint detection, drying, and milling with an efficient, cost-effective granulating process that utilizes a limited amount of water and does not require a drying step.

Because this process depends on the addition of a moisture absorber to facilitate even moisture distribution and drying of the granulated powder, careful selection of excipient is critical for its effectiveness3. SYLOID® XDP mesoporous silica excipient from Grace serves as a highly effective moisture absorber with its high surface area and pore volume coupled with an active silica surface. SYLOID® XDP silica effectively “locks” away moisture in its pores to create a stable, dry powder. Also, SYLOID® XDP silica’s large particle size promotes a blend with improved flow characteristics for easier processing.