Application Note

Nitrogen Purge Optimization And Validation Of Sterile Liquid Filling Lines

Nitrogen Purge Optimization And Validation Of Sterile Liquid Filling Lines

Sterile liquid filling lines are increasingly being implemented with nitrogen purge capability during filling. Large molecule biopharmaceuticals can be prone to oxidation and to prevent this from occurring, the headspace is often purged with an inert gas during filling to ensure a longer shelf life. The use of a fast and robust oxygen monitoring method can significantly streamline the set up and validation of a filling line. For these reasons, laser-based headspace analysis is often the method of choice for monitoring headspace oxygen levels during filling.

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