Non-Invasive Headspace Analysis For Automated Media Fill Microbial Inspection
![Detection of Microbial Contamination In Sterile Containers Using Headspace Analysis Detection of Microbial Contamination In Sterile Containers Using Headspace Analysis](https://vertassets.blob.core.windows.net/image/f3e339b0/f3e339b0-eff8-4bfe-9729-129046905f52/375_250-img_3939.jpg)
Sterility testing in the pharmaceutical industry has long been based on growth media culture methods. The general approach is to incubate for 14 days and then determine potential contamination with a visual inspection of the media sample. Over the last decade a number of Rapid Microbial Methods based on various analytical techniques have been implemented. These provide quicker, more sensitive, accurate, and reproducible test results when compared with conventional, growth-based methods. Recently, it has been demonstrated that laser-based headspace provides yet another alternative approach for detecting microbial contamination in sterile pharmaceutical product. Applications for this method include automated media fill inspection and rapid non-destructive contamination testing directly in finished product containers.
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