Application Note: Online Monitoring Particle Milling - Employing A High Shear Mixer

In the production of medicines it is often difficult to target a specific and appropriate active pharmaceutical ingredient (API) particle size. The surface area per unit of mass, or specific surface area, increases as the particle dimension decreases, affecting the therapeutic efficacy of drug compounds that have low in vivo solubility. Thus, particle size reduction is often an important step in the production of an effective pharmaceutical formulation.