Organ-Chips And Animal Models: Sensitivity Explained

In a recent study, researchers at Emulate reported that the human Liver-Chip, an advanced three-dimensional culture system that simulates human liver tissue, could potentially have saved over 240 lives and prevented 10 liver transplants caused by the test set of drugs. Any preclinical model capable of preventing toxic drugs from reaching patients would be invaluable, but its effectiveness largely depends upon its sensitivity. Sensitivity, within the context of predictive toxicology, measures how adeptly a model can detect the toxicity of a drug candidate. Learn in detail about the limitations of animal models in predicting drug toxicity, and explore the potential of organ-chip technologies, specifically the Liver-Chip, in enhancing preclinical drug development and filling the sensitivity gap observed in animal models.