Particle Size Engineering Through Micronization

Stability, flowability, dissolution rate and bioavailability (BA) are all critical performance parameters impacted by the size distribution of particles. As part of our integrated product development services, Lonza Pharma & Biotech offers premier particle engineering capability through micronization, from early stage design through scale-up and commercial quantities. We are well versed in particle size reduction to low-micron or sub-micron levels — which plays an important role in effective drug delivery.

Full service micronization services
Particle size reduction through micronization is a core capability of Lonza. Decades of jet milling experience with more than 1000 drug compounds has led to premier capabilities and expertise in micronization and particle classification. Specialized and phase-appropriate jet mills and labs are in place to support early stage development studies. Clinical and commercial scale production leverages the processing and process validation from early stage studies.

Wide-ranging applications
Micronization and nano-milling are used routinely in many applications in solid oral and other dosage forms.

• Enhance BA through dissolution optimization for oral drugs
• Help solubilize and stabilize poorly soluble compounds in the development of multiparticulate systems, as well as drug emulsions and suspensions
• Improve the palatability properties of a compound
• Generate particles fine enough to be properly delivered to the lungs (for inhalation product development)
• Help ensure absorption of a drug across the skin (in the development of transdermal products)