Pharmaceutical Characterization: Particle Size Analysis

Particle size is an important characteristic for many dosage forms. Stability, flowability, dissolution rate, and bioavailabilty are among the parameters affected by the size distribution of particles. Cirrus Pharmaceuticals, Inc. provides a wide range of services to meet our clients' particle sizing needs, from formulation development to in-line process monitoring to quality control and release of finished product. Our highly trained scientists carry out particle sizing method development, validation, and routine analysis under cGMP guidelines to address the complexities of technical and regulatory challenges.

Particle size reduction is often used to:

• Generate particles fine enough to be properly delivered to the lungs (for inhalation product development).
• Enhance bioavailability of oral drugs across the intestinal epithelium (in the development of tablets and capsules).
• Help enhance absorption of a drug across the skin (in the development of transdermal products).
• Help with solubilizing poorly soluble compounds as in the development of emulsions and suspensions or microparticulate systems.
• Enhance bioavailability.
• Speed the dissolution rate of a drug.
• Enhance flow characteristics of powders.
• Enhance wetting properties to improve solubility.
• Improve drug stability and the taste properties of a compound.