Datasheet | December 7, 2010

Data Sheet: Fluid Jet Mill Micronization

Source: PharmaSystems, Inc.

With the term micronization it is indicated a method of reduction of the dimensions that concurs to obtain powders under the 10 µm of size, in particular our fluid jet micronizers concur to obtain an extremely narrow tight particle size distribution curve of d100<5 µm (100% below 5 µm) and d99<3 µm (99% below 3 µm) or even less depending by product nature.

This technology is extremely important in different industrial fields, in particular in the druggist field the reduction of the active principles (the so-called API and HPAI) to such dimensions increases exponentially the characteristics of Bioavailability, of Bioequivalence, and the surface area available of the product.

These equipments are manufactured entirely with stainless steel Aisi 316L, but they can also be realized with super alloy such as Hastelloy C-22 and now also with glass process side. The process sides do not show visible welding and are finished with mechanical mirror polishing and afterwards with electro-polishing process in order to reach a final roughness value below of 0.10 µm. All the manufacturing processes are carried out according to registered procedures in such way to guarantee the same high constant quality at any time and, in this way, we are able to supply all the necessary documents for the process of validation of the equipment for the druggist use.

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