Precision In Every Step: The Dosing Process Behind The Perfect Inhalation Powder

Bringing an inhalable dry powder drug candidate to market demands rigorous synchronization between powder formulation, delivery device performance, and high-speed filling technology. Active pharmaceutical ingredients exhibit diverse rheological characteristics and cohesive behaviors, making early material characterization critical to preventing agglomeration and ensuring uniform dosage distribution. Advanced analytical tools like the Next Generation Impactor allow research teams to evaluate aerodynamic particle size distribution early, ensuring optimal dispersion upon patient inhalation. Evaluating dosing methods on benchtop instrumentation provides vital volumetric insights before scaling up to high-speed commercial filling lines. Early-stage testing mitigates risk, accelerates development timelines, and ensures robust product quality throughout commercialization. Read the full article to discover critical milestones for engineering commercially viable dry powder inhalation therapies.

Harro Höfliger designs, engineers and manufactures state-of-the-art production equipment for pharmaceutical and medical device clients around the world. Our global presence in automation technologies facilitates production in:

• Medical and Parenteral Device Assembly
• Pharmaceutical Dosing Technologies
• Capsule Filling and Weighing
• Cell and Gene Therapy Automation
• Aseptic Applications
• Packaging Equipment
• Diagnostics Manufacturing
• Surgical Suture Production
• Inhalation Dosing and Assembly
• Web Processing and Converting
• Eye Care and Contact Lense Manufacturing
• Wound Care, Transdermal, and Oral Dissolvable Film Production

Whether your application requires manufacturing, assembly, filling, sealing, packaging, technical consulting – or any combination of the above – Harro Höfliger brings 50+ years of expertise to each customer’s unique pharmaceutical and/or medical device project. No matter if your product is in the laboratory and development phase or it demands commercial production, our global team of engineers, designers, pharmacists, and customer service providers are equipped to support the success of each project, well into its future.