Product Characterization Services Brochure

Product characterization is the foundation for all formulation and process development. BTL use a range of specific analyses to understand the behaviour of your product throughout the different stages of the freeze drying process, and the impact of the different components within it.

Freeze Drying Microscopy is a popular and well established lyophilisation analysis technique. Investigation using BTL’s own Lyostat instrument allows determination of key critical temperatures, such as the eutectic melting temperature (Teu) and collapse temperature (Tc), as well as the identification of crystallisation phenomena, skin/ crust formation, and the effects of annealing on ice crystal growth and solute structure. Knowledge of the critical temperatures is essential to conduct cycle development on a rational, quantitative scientific basis as well as saving precious resources in terms of time and monies needed.